On a similar if sillier note note, Korg made a Hatsune Miku guitar effect[1] that was programmable through audio sent from an iPhone app through the guitar pickup.

Annoyingly, the free app isn't available on the US App Store, so open source software would be useful (insofar as the ability to play back a predefined sequence of Vocaloid phonemes using an electric guitar is useful).

[1] https://www.korg.com/us/products/effects/mikustomp/