People overemphasize the "time loop trap" piece but seem to overlook the fact that he eventually uses the time to better himself in almost every way. He's a much better, much more enriched and happy person by the end.
The biggest thing holding people back imo is fear of failure, fear of consequences.
If your dream is starting a business but if it fails you'll be broke, it's understandable if you're hesitant
Fear of failure cripples people because setbacks are so costly. Many people never attempt anything because they are afraid they will fail. Or more accurately because they cannot afford to fail
If you mean it in the sense that 'ultimately, nothing really matters', then the subtext to that is that nothing ultimately matters because we all die in the end. Which would be completely negated by immortality.