Re:Schizophrenia study finds new biomarker, drug candidate i...
by interiorchurch on Friday March 20, 2026 @11:07AM
(#47455687)
I remember reading in Courtenay Harding's (now very old) book, Recovery from Schizophrenia: Evidence, History, and Hope, that populations with a higher prevalence of bipolar tended to have a lower prevalence of schizophrenia, and vice versa. The implication was that the same thing was being expressed differently in differing contexts. I would be curious if more contemporary studies bore this out.
Re:Schizophrenia study finds new biomarker, drug candidate i...
by asveikau on Friday March 20, 2026 @11:33AM
(#47456065)
I believe I've heard that synaptic pruning may be implicated in both.
Re:Schizophrenia study finds new biomarker, drug candidate i...
by tokai on Friday March 20, 2026 @12:03PM
(#47456550)
The overlap is not huge at all. Beside psychosis, they have no overlap, and the quality of the psychosis in the two illnesses is far removed from each other.
Re:Schizophrenia study finds new biomarker, drug candidate i...
by asveikau on Friday March 20, 2026 @12:19PM
(#47456798)
I'm speaking about people I've known and been close to. As an example, my brother shifted around diagnosis between bipolar I, schizoaffective, and schizophrenia often while I was growing up. He's not the only person I know like this. I've spoken to psychiatrists about the ambiguity between these diagnoses.
I also know of numerous people who have spoken publicly about receiving a schizophrenia diagnosis and having it later be revised to schizoaffective disorder.
I also came to the impression that it is common to receive a bipolar I diagnosis during a psychotic episode and have it later the diagnosed as schizophrenia or schizoaffective disorder.
Sometimes if your doctor sucks you may stay in the less accurate diagnosis, sometimes for years.
Re:Schizophrenia study finds new biomarker, drug candidate i...
by olladecarne on Friday March 20, 2026 @01:13PM
(#47457568)
Same in someone I know, shifted between bipolar and schitzoaffective and schitzophrenia. Bipolar during manic episode, later schizoaffective. A lot of paranoia and also delusions, but also refused medication due to side effects (and probably the disorder itself).
I'm a non expert but I believe some people are starting to see it that way. See: https://www.google.com/search?q=schizophrenia+spectrum+disor...
Also there's huge overlap in symptoms between bipolar I with psychosis, schizoaffective disorder, and schizophrenia. People sometimes move around between these diagnoses throughout treatment, different doctors have different opinions, patient behavior changes, etc.
I personally think these symptoms come about through many different causes and the labels are somewhat inadequate. They capture a symptom profile rather than a full understanding.