Adenosine on the common path of rapid antidepressant action: The coffee paradox

Re:Adenosine on the common path of rapid antidepressant acti... by MilkyWayMasta on Friday December 05, 2025 @07:50PM (#46169404)

"The mechanism of action of ketamine primarily involves modulation of mitochondrial metabolism as opposed to NMDA receptor antagonism"

More evidence for Chris Palmer's 'Metabolic Theory of Mental Disorders'

[ Parent | on HN ]

Re:Adenosine on the common path of rapid antidepressant acti... by Muromec on Friday December 05, 2025 @08:18PM (#46169573)

It kinda makes sense if you consider depression to be a mechanism to get into winter hibernation. It's just we can't hibernate and even if we could, somebody has to pay them bills.

[ Parent | on HN ]

Re:Adenosine on the common path of rapid antidepressant acti... by leobg on Saturday December 06, 2025 @04:17AM (#46171864)

That was the funniest social critique I’ve heard in a long time.

[ Parent | on HN ]

Re:Adenosine on the common path of rapid antidepressant acti... by port11 on Saturday December 06, 2025 @09:42AM (#46173705)

But are we built for hibernation? Or is the capacity for depression just a biological mistake for us?

[ Parent | on HN ]

Re:Adenosine on the common path of rapid antidepressant acti... by Muromec on Saturday December 06, 2025 @05:01PM (#46176958)

We are not build for anything. It's a legacy codebase. Some stuff stopped working, but nobody removed the surrounding utility codes and the config entry to enable it.

[ Parent | on HN ]

Re:Adenosine on the common path of rapid antidepressant acti... by port11 on Sunday December 07, 2025 @01:29AM (#46179624)

Damned legacy code and technical debt always ruining everything.

[ Parent | on HN ]