I'm not saying it is a perfect analogy, but it is by far the most familiar one for people to describe what sparse activation means. I'm no big fan of over-reliance on biological metaphor in this field, but I think this is skewing a bit on the pedantic side.
re: your second comment about pruning, not to get in the weeds but I think there have been a few unique cases where people did lose some of their brain and the brain essentially routed around it.
Typically, input gets routed to a number of of experts eg. top 2, leaving the others inactive. This reduces number of activation / processing requirements.
Mistral is an example of a model that's designed like this. Clever people created converters to transform dense models to MOE models. These days many popular models are also available in MOE configuration
(commentary: things are really moving too fast for the layperson to keep up)