Anything dealing with the signaling systems of the body (GLP-1 agonists, DP-XX binders like Keytruda, IL-XX binders like Humira, etc and even HRT) all fall under this bucket. We have a great understanding of some effects of some signaling systems and we use that understanding to our advantage. But the fact is these signaling molecules and receptors do a lot, more than we know, and in overlapping and complex ways, that we are always finding “new indications” and “new side effects” with roughly equal frequency.