>Depression is likely to have many possible underlying causes

including adaptive evolutionary procreative success

Correct.

and one of the leading causes is what I described.

You really have to unpack "detox inefficiency" because even a google search comes back with nothing.

When your normal lymphatic processes (and glymphatic processes) are slowed, or near-halted.

Is there a known correlation between lymphedema and depression?

Can you link any evidence supporting this claim?

Beyond the links in other comments?

No, ones that would support your claim.

And at least mention terms you used.

Do you not count depression as a mood disorder…?

It might be worth using those words rather than detox inefficiency because the latter conjures thoughts of woo peddlers.

Yes,

it turns out toxins (environmental, die-off and waste of cells from infection, dietary, lifestyle) are important to everyone,

not just vegans in Sandler movies.

Calling it lymphatic impairment would be more straightforward.

Lymphatic inefficiency, maybe.

Impairment sounds too permanent, when this is often an intermittent, “on average” sort of issue - not a complete freeze.