This matches my understanding as well, as someone who has a great deal of interest in the field but never worked in it professionally. CPUs all have a microarchitecture that doesn't look like the ISA at all, and they have an instruction decoder that translates ISA one or more ISA instructions into zero or more microarchitectural instructions. There are some advantages to having a more regular ISA, such as the ability to more easily decode multiple instructions in parallel if they're all the same size or having to spend fewer transistors on the instruction decoder, but for the big superscalar chips we all have in our desktops and laptops and phones, the drawbacks are tiny.

I imagine that the difference is much greater for the tiny in-order CPUs we find in MCUs though, just because an amd64 decoder would be a comparatively much larger fraction of the transistor budget