The other mode is with a nodejs server (it's what I'm using). This allows me to access the wiki from all devices.
I forget that File -> Save is even a thing for websites.
It's not perfect, though. Paragraphs are rendered by using two br tags, instead of p tags. Link syntax is the reverse of MediaWiki syntax; i.e. [[foo|bar]] links to "foo" in MediaWiki, but "bar" on TiddlyWiki, which trips me up constantly. There's other syntax awkwardness like sensitivity to spacing and newlines. Journals sort in alphabetical, not chronological order.
It is a common gotcha that new users will lose some of their work while they learn persistence.
With TiddlyWiki you had to essentially File -> Save As and save the HTML back over itself. There were other ways too but they were all workarounds to the issue that browsers don't allow direct access.
I thought opening index.html in the browser was basically just a demo.