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Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by godshatter on Tuesday August 05, 2025 @04:00PM (#44803481)
I'm not a fan because it's expensive and once you go off of the drug the weight comes back on (at least from what I've read). That's not a trade-off I want to take lightly.

There's also something to be said for gaining the discipline to do it yourself along the way, which may lead to keeping more of the weight off in the long run.

We also don't know what the long term side effects of it will be, if any.

I don't find any of that unreasonable to me. I'm saying this as a type-2 diabetic who could stand to lose a lot of weight.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by Someone1234 on Tuesday August 05, 2025 @04:12PM (#44803638)
> We also don't know what the long term side effects of it will be, if any.

The first GLP‑1 receptor agonist was commercially released in April 2005, meaning 20+ years. People who often repeat this: If 20-years, and tens of trials, isn't long enough to "know" then where is the line exactly?

Thalidomide by contrast was available for 4-years, Vioxx for 5-years, and Rezulin for 3-years by contrast.

> There's also something to be said for gaining the discipline to do it yourself along the way, which may lead to keeping more of the weight off in the long run.

That doesn't work; we know it doesn't work both from small and large scale studies, and population evidence since 1970s. So you're promoting the same thing we've been doing, and failing at, for beyond all of my lifetime. Feels like a religious belief at this point, rather than following the data and what we know from it (i.e. that objectively does not work, and has never worked).

Is there something new you know that health experts haven't known as Obesity as increase up through 40.3%+ (with overweight being 73.6%+)?

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by jonny_eh on Wednesday August 06, 2025 @12:08AM (#44807536)
> We also don't know what the long term side effects of it will be, if any.

What are the long term side effects of NOT taking it? The article implies it could be early death.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by glp1guide on Wednesday August 06, 2025 @12:44AM (#44807722)
> I'm not a fan because it's expensive and once you go off of the drug the weight comes back on (at least from what I've read). That's not a trade-off I want to take lightly.

This isn't true

https://glp1.guide/content/do-people-regain-all-the-weight-l...

The rest of the incorrect points other people have basically covered, so won't repeat.

Is teaching the discipline lesson worth the shorter life people would live without this medication? Maybe we could find another way to teach people discipline that doesn't maintain a threat to their health?

> I don't find any of that unreasonable to me. I'm saying this as a type-2 diabetic who could stand to lose a lot of weight.

Gonna be incredibly blunt, but talk to your doctor and get on GLP1s. Take a low dose if you want.

GLP1s are incredibly well researched and effective. Imagine dying of a heart attack early because you refused to properly research effective, low-risk medication that is being used by millions and recommended by professional organizations and doctors widely. Real Steve Jobs energy.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by astrange on Wednesday August 06, 2025 @03:03AM (#44808638)
"Discipline" doesn't exist, or rather it's a feature of your brain and not something you can necessarily learn. GLP-1 inhibitors and stimulants (modafinil, amphetamine, etc) are drugs that literally give you "discipline".

Habits are something you can learn though, and having more discipline helps you form them.