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A comment on Psilocybin treatment extends cellular lifespan, improves survival of aged mice. Parent comment

Re:Psilocybin treatment extends cellular lifespan, improves ... by titanomachy on Thursday July 24, 2025 @05:24PM (#44676384)
I don’t think you multiplied quite right. An 80-kg person would need 400mg, which would take 40g of shrooms if potency is 10mg per dried gram.

That would still be 10 times larger than a regular dose. I think that would make most people seriously ill, not to mention the mental effects. One must assume that mice respond differently than humans.

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Re:Psilocybin treatment extends cellular lifespan, improves ... by andoando on Thursday July 24, 2025 @05:28PM (#44676431)
Yeah someone also brought up that its not a linear scaling. https://pmc.ncbi.nlm.nih.gov/articles/PMC4804402/

And the study calculates it a 5mg for rats as 25mg for humans.

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Re:Psilocybin treatment extends cellular lifespan, improves ... by yusaydat on Friday July 25, 2025 @12:04PM (#44684744)
It's 5 mg/kg (or 15 mg/kg due to faster metabolism) for rats, and 25 mg (not per kg!) for humans. To be clear, 25 mg is a completely normal dosage that has been used in previous human studies.
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