Well your perception of time would certainly be longer at that dose. Probably feel like you've lived for centuries.

I can confirm. The wheel turned many times.

I don’t think you multiplied quite right. An 80-kg person would need 400mg, which would take 40g of shrooms if potency is 10mg per dried gram.

That would still be 10 times larger than a regular dose. I think that would make most people seriously ill, not to mention the mental effects. One must assume that mice respond differently than humans.

Yeah someone also brought up that its not a linear scaling. https://pmc.ncbi.nlm.nih.gov/articles/PMC4804402/

And the study calculates it a 5mg for rats as 25mg for humans.

It's 5 mg/kg (or 15 mg/kg due to faster metabolism) for rats, and 25 mg (not per kg!) for humans. To be clear, 25 mg is a completely normal dosage that has been used in previous human studies.

After a few days, such a dose would likely become imperceptible in “healthy normals.”

Your two statements contradict

If 1g of shrooms has 5mg psilocybin, to get a dose of 5mg/kg would be like 75g for an average man (still feels very high but nowhere near 1kg)

Sorry did the math completely wrong. And this was a monthly dose, for 75g thats ~2.5g a day

Ah yes, a proper morning routine. A bit of coffee, exercise, becoming one with the void…

"First, we sought to model high-dose used in a clinical study for chronic pain, where patients were administered a psychedelic dose (25 mg) of psilocybin. Using the standard allometric scaling method, a human dose of 25 mg of psilocybin translates to a mouse dose of approximately 5.14 mg/kg."

Interesting. I thought linear would obviously be incorrect, but didn't think it scaled so strongly.

At 25mg, thats 2.5g first month and 7.5g monthly afterwards. I wonder if the effects are the same with monthly injections vs daily though.