I am a convert, once you get the hang of the configurability it's very good (Tailwind 4). You don't have to go to separate files which is more streamlined, esp when doing in React.

I like to format in logical chunks per line, for example here's a pretty complex grid setup that is easy to adjust in the template:

    ----
    <section className="
      w-full
      px-8 py-16
      md:px-16
    ">
      <div className="
        grid
        gap-2
        auto-rows-[minmax(0px,1fr)]
        grid-cols-[repeat(1,minmax(4rem,1fr))]
        grid-rows-[repeat(1,minmax(4rem,1fr))]
        md:grid-cols-[repeat(6,minmax(6rem,1fr))]
        md:grid-rows-[repeat(3,minmax(6rem,1fr))]
        xl:grid-cols-[repeat(8,minmax(6rem,1fr))]
        xl:grid-rows-[repeat(2,minmax(2rem,1fr))]
        justify-center
        ">
    ----