For UKI I imagine a big hurdle is the size of the images (given /boot/efi is usually only big enough for bootloaders, not kernels and initram) and custom kernel modules (e.g. Nvidia).

There was some systemd work on a spec for a boot partition to extend the efi partition for storing kernel images and initramfs, but I don't think any distro currently defaults to it on.

I think hibernation is currently also broken, since the hibernation file is stored unencrypted by default and thus can't be used with secure boot.