I've used it as my desktops main filesystem for many years and not had any problems. I have regular snapshots with snapper. I run the latest kernel, so ZFS is not an option.

That said, I avoid it like the plague on servers, to get acceptable performance (or avoid fragmentation) with VMs or databases you need to disable COW which disables many of it's features, so it's better just to roll with XFS (and get pseudo-snapshots anyway).