> Somehow that trait was evolutionary helpful (groupwise, not necessarily for a single being)?

There’s plenty of people that have degenerative diseases with no perceivable benefit that are “evolutionary” favored due to genetics just working out that way. What does Huntington’s disease provide? Its a dominant gene, doesn’t typically effect people until they’re 30 or 40 past their prime child years.

> In general just lowering _any_ cholesterol without understanding _all_ the cons and pros won't cut it.

Pros: it significantly decreases long term of risk of cardiovascular disease later in life

Cons: the medications have to be taken daily forever, I guess.

This is just an argument from nature. If you have very high cholesterol, there’s no good reason to not lower it to sub-problematic levels.