Adipose tissue retains an epigenetic memory of obesity after weight loss

Re:Adipose tissue retains an epigenetic memory of obesity af... by joncrane on Thursday April 17, 2025 @12:04PM (#43718768)

This is interesting because about 20 or so years ago when I was super into bodybuilding, you couldn't talk about a "cycle" on a bodybuilding forum without talking about a "post cycle protocol."

I know that's different than permanent TRT but I feel like you couldn't get very far researching that stuff without understanding that you natural test production (and sperm production) would get "shut down" as soon as you started adding exogenous androgens.

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Re:Adipose tissue retains an epigenetic memory of obesity af... by Aurornis on Thursday April 17, 2025 @12:11PM (#43718868)

Yeah, it's well known that steroids shut you down. The problem with the broscience is that the PCT is talked about like it reverses everything like an antidote, but long-term bodybuilders often end up on TRT because eventually they can't get back to baseline.

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Re:Adipose tissue retains an epigenetic memory of obesity af... by gr3ml1n on Thursday April 17, 2025 @03:35PM (#43721169)

That isn't true. Dedicated bodybuilders, starting more commonly ~5 years ago, decided that PCT wasn't worth it. Instead of typical 16-20 week cycles followed by 4-6 weeks of PCT, they adjust the dose between supraphysiological and (generally) top-of-normal, i.e.: blast and cruise.

It's not because they couldn't recover, it's because they don't want to or see the point.

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