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Re:Adipose tissue retains an epigenetic memory of obesity af... by mkoubaa on Thursday April 17, 2025 @09:11AM (#43716298)
I am pretty sure the only way to reduce the number of cells is liposuction
Re:Adipose tissue retains an epigenetic memory of obesity af... by rcruzeiro on Thursday April 17, 2025 @09:18AM (#43716396)
Worse than that. Subcutaneous fat (which is the one you can trim off with liposuction) usually expands relying more in cell expansion and not in hyperplasia. Visceral fat on the other hand, is way more likely to involve hyperplasia and you cannot use liposuction against this type of fat. This is also the fat that is very hormonally active and increases the risks of diabetes, heart disease, cancers, strokes.
Re:Adipose tissue retains an epigenetic memory of obesity af... by gosub100 on Thursday April 17, 2025 @09:56AM (#43716929)
Is it unremovable because it's inside the core muscles and near internal organs?
Re:Adipose tissue retains an epigenetic memory of obesity af... by meindnoch on Thursday April 17, 2025 @10:31AM (#43717426)
See the second half of this video: https://www.youtube.com/watch?v=Bav_IBsuXEM

Visceral fat is literally enclosing the intestines, major blood vessels, organs, etc. of the abdomen.

Nevertheless, it is possible to surgically remove this sheet of fat that's covering your organs, it's called an omentectomy. But it's a big surgery, and done only in case of cancer, not for weight loss. That is, in humans: https://pubmed.ncbi.nlm.nih.gov/29367725/

Re:Adipose tissue retains an epigenetic memory of obesity af... by nradov on Thursday April 17, 2025 @10:15AM (#43717185)
Right. A surgeon can't just stick a liposuction tube into the abdominal cavity and poke around. This would be major invasive surgery with a high risk of complications, far worse than leaving the adipose tissue in place.
Re:Adipose tissue retains an epigenetic memory of obesity af... by BurningFrog on Thursday April 17, 2025 @09:25AM (#43716473)
I've been wondering about that. Like all cosmetic surgery liposuction is looked down upon.

But maybe it can also be a useful and healthy weight loss strategy?

Re:Adipose tissue retains an epigenetic memory of obesity af... by bognition on Thursday April 17, 2025 @09:52AM (#43716859)
Despite being looked down on, it's still very common. I know several people who have had liposuction. The results are only temporary. Everyone I know that has had this procedure has rebounded back to their original body weight within 2 years.
Re:Adipose tissue retains an epigenetic memory of obesity af... by mapkkk on Sunday April 20, 2025 @09:19AM (#43743595)
Liposuction is actually a very risky procedure, at least in relation to its benefits. For example, fat embolisms in liposuction occur in 8-9% of patients that undergo the procedure. There are other risks that are non-trivial as well.

If I had to advise a patient on whether they should consider liposuction vs gastric bypass vs GLP1R agonists, I would tell them to not consider liposuction in that equation at all.

As with most cosmetic surgery, risks like these are downplayed by practitioners (willfully and otherwise) as well as by people in these social media circles.

This doesn't mean liposuction shouldn't ever be used, however. It can have good uses in reconstructive surgery, for example, where fat is sucked up to be used in reconstructing a different area. In this case, the potential reduction in morbidity and restoration of function to the patient, or increasing their autonomy, might make the risks associated with lipo worth it.