You can run Trisquel Mate, but you need to set the propietary kernel and CUDA on your own. You can use the Xanmod kernel, the headers and the prop NV installer, but you will be less free on freedoom. With Intel and OpenCL (or whatever intel uses today), you might loss performance, but you gain compatibility and you are not bound to Intel X86, in case you want to try further Power9 based stations.