Ketamine for Depression: How It Works

Re:Ketamine for Depression: How It Works by throw-qqqqq on Friday February 07, 2025 @04:53PM (#42977933)

A friend of a friend took MDMA + Ketamine every weekend. K-hole doses. Developed monday-blues which turned into a sort of servere depression as he pressed on. It took a year of abstinence before he felt “normal” again.

Drugs that affect the serotonine system can do this. Burnout from (repeated) overload sort of situation IIUC.

I’m no doctor, but I suspect it’s extra dangerous if you’re already suffering depression.

I couldn’t read the whole note. What a tragedy :'(

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Re:Ketamine for Depression: How It Works by golergka on Friday February 07, 2025 @05:16PM (#42978134)

Taking MDMA every weekend is like drinking a few glasses of hard liquor every day. Meaning, only completely delusional and uninformed people would think it won't destroy your life.

Of course, many people still do it. But they are fully aware of what road they're taking.

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Re:Ketamine for Depression: How It Works by siva7 on Saturday February 08, 2025 @04:01AM (#42981576)

Trust me, the drugs won't do this..

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Re:Ketamine for Depression: How It Works by solumunus on Saturday February 08, 2025 @06:31AM (#42982240)

I took MDMA every weekend and it seriously fucked me up. I was depressed for easily a year afterwards.

I suspect even 15 years on I haven’t fully regained my ability to experience joy, but this is impossible to know for sure. I can’t run the counter factual and there are many other variables at play. I was a teenager when I got too deep into MDMA.

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