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Re:Bacteria (and Their Metabolites) and Depression by bell-cot on Wednesday January 29, 2025 @07:11AM (#42864015)
The dose makes the poison. And the phrase "absorbed through the skin" admits a very wide range of absorption rates.
Re:Bacteria (and Their Metabolites) and Depression by londons_explore on Wednesday January 29, 2025 @07:34AM (#42864152)
Interestingly there are some materials the absorb through the skin far faster than you'd expect. ie. they soak in just like a tissue soaks up water.
Re:Bacteria (and Their Metabolites) and Depression by gilleain on Wednesday January 29, 2025 @07:49AM (#42864297)
Dimethylmercury, for example. https://en.wikipedia.org/wiki/Dimethylmercury
Re:Bacteria (and Their Metabolites) and Depression by bell-cot on Wednesday January 29, 2025 @11:38AM (#42867279)
True...but Hg(CH3)2 is so much of a "MSDS from the 11th circle of hell" corner case that only expendables in heavily armored moon suits should ever go near the stuff.
Re:Bacteria (and Their Metabolites) and Depression by MaKey on Wednesday January 29, 2025 @12:00PM (#42867704)
Yet a German synthesized it in his basement and used it to poison a colleague: https://www.theguardian.com/world/2019/mar/07/german-who-poi...

A crime as heinous as the substance that was used. It's a miracle that he didn't kill himself or one of his family members with it.

Re:Bacteria (and Their Metabolites) and Depression by sethammons on Wednesday January 29, 2025 @07:43AM (#42864237)
hydrofluoric acid. Get some on your skin, and you don't even feel a burn. But within minutes or hours, you may have demineralized your bones, causing them to go beyond brittle
Re:Bacteria (and Their Metabolites) and Depression by FollowingTheDao on Wednesday January 29, 2025 @07:40AM (#42864203)
The paper seems to conclude that we do not know the safe dose. And we are not talking death, but suffering.

So taken together, there would seem to be good reason to continue to continue to unravel the long-hypothesized inflammation/depression connection, and particularly in regards to possible exacerbating factors such as higher levels of M. morganii infection or even higher environmental exposure to diethanolamine. We seem to have a lot to learn here!