I've looked into it briefly but it seems like too much work for me right now.
The True Genode Way of course is that everything worth having would eventually be ported as a native genode component instead of a qubes style VM. They've put a lot of effort into making that as easy as they can with Goa (a nix-inspired package management and build tool) and adding to their C standard library and ports of popular 3rd party libs like SDL
They dont assume you want a RAM-Only filesystem by default. It starts out completely immutable with nothing being able to save anything anywhere.
If you want to save anything to a hard drive you have to enable that driver because they don't assume that you'd need one.
Copy and paste is an optional extra to install
It's wild :p
I like the idea of Qubes and it looks like Genode might be an even better idea...