I was trying to find words to say much the same. 5% variance could in principle be enough to alter homeostasis reactions in the hormone system. Maybe I misunderstand but the self-regulation mechanisms inside the body can titrate inside this level can't they? So the question would be if 5% variance in some things could alter blood levels over time, or how the liver reacts.

I don't live in a high corn syrup economy. I'm not exposed to the risk as much, I'd be blovating to say much here.

I also wonder if the artificial sweeteners are bad, precisely because of biomimcry: Fooling the body into thinking it's ingested sugar could have perverse outcomes.