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Re:Fish have a brain microbiome – could humans have one too? by dekhn on Monday December 02, 2024 @02:30PM (#42299487)
From what I understand about the BBB, it's practically impermeable to anything the size of a bacteria (mainly intended for gating small molecules like fats and drugs), until an individual has some sort of disease or other health problem that effects the BBB's integrity. But I can easily imagine that some bacteria (harmful, or helpful) could have exactly the right surface proteins to indicate it's permitted.

I guess this review/writeup https://asm.org/articles/2020/april/how-pathogens-penetrate-... covers most of the known mechanisms for traveral of the BBB by pathogens.

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