This reminds me when EU banned some eye drops with the product name Proculin which have been very effective. The replacement Berberil is useless, literally no effect.

Proculin made your eyes white white constricting the blood vessels for hours. All the stoners had it in their pockets.

Since it constricted blood vessels one could use it also to reduce the local inflammation on pimples, which was a neat off label usage.