There have previously been associations between caloric intake and Alzheimer Disease or Cognitive Aging, for example:

https://jamanetwork.com/journals/jamaneurology/fullarticle/7... https://www.pnas.org/doi/10.1073/pnas.0808587106

I think it's a fair bit of a stretch to broadly say that this study shows an association.

> Conclusion: Higher intake of calories and fats may be associated with higher risk of [Alzheimer Disease] in individuals carrying the apolipoprotein E ϵ4 allele.

> The hazard ratios of [Alzheimer Disease] for the highest quartiles of calorie and fat intake compared with the lowest quartiles in individuals without the apolipoprotein E ϵ4 allele were close to 1 and were not statistically significant.

For the general population, there was no correlation. Identifying specific genetic outliers where there may be a connection is still useful, but far from a general result.

Exactly. There are lots of skinny alcoholics and drug addicts. Unfortunately many of them are homeless.

The real surprise I learned is that GLP-1 may discourage other addictions as well, including gambling. Source: A nurse I talked to who works with GLP-1 trials.

As others have already stated, it’s starting to become mainstream science that there is a strong correlation between obesity/poor body composition and Alzheimers. It’s not settled science yet, but the correlation is starting to look a whole lot like causation at a society level.

Not to cite anecdotal evidence, but my father-in-law was skinny as a rail and got severe, early-onset Alzheimer's. Obesity might be one potential cause of Alzheimer's, but it's among many.

Yep, just like there are skinny as rails type 2 diabetics. My grandfather was one.

There is also a huge correlation between obesity and type 2 diabetes as well.

I imagine they share similarities, but that’s pure speculation.

Alzheimer's is now being referred as type 3 diabetes for a reason.

Human metabolism is sensitive to the type of food you eat.

Check https://www.metabolicmind.org/ as a starting point and follow the rabbit hole to understand the link between what you eat and mental and metabolic illness.

Also, GLP-1 also eliminates muscle - your heart is a muscle.

GLP-1 reduces calorie intake and puts many people on a deficit (typically on purpose). This of course will reduce muscle just like any other calorie deficit anyone runs long term.

Fasting increases growth hormone release (dramatically, in the case of extended fasting), which counters muscle loss. Does this happen with GLP-1?

This goes against all evidence I have seen for folks who have lost a drastic amount of weight very rapidly. Bodybuilders seem to see the same effect as well when on cuts.

When you are losing 5% of your bodyweight per month (as I was, and many do) a substantial portion of that is simply going to be mean muscle mass. You can counteract some, but not all, of this by heavy resistance training. It's very difficult to not lose muscle mass while losing weight - it takes extreme measures for most folks (e.g. athletes) to do so.

> Alzheimer's is now being referred as type 3 diabetes for a reason.

No it's not.

Some are referring to it that way

https://pmc.ncbi.nlm.nih.gov/articles/PMC2769828/#:~:text=We....

What you eat is a very different concept to the amount you eat. Especially on topics like these, the distinction is critical.

>If it was as simple as eating less makes these issues go away, we would've figured that out a long long time ago.

You can't get people in large enough quantities to do that reliably and for long enough as part of a study. Best you can do is a small quantity of lab rats.

The data is already rolling in as part of prescribed out-patient data.