It's the few instances of new onset IBD and generally the GI side effects. I'm lucky enough to have a pretty solid GI system that I don't want to risk messing with. I get very anxious with medicine, and my ankylosing spondylitis is sufficiently slow moving on MRI and tolerable enough that I prefer not to use the medicines. I had too many strange side effects whilst on Humira/Remicade such that it scares the crap out of me.

Understandable. I'll just say that for a sample size of n=1 I've seen no GI side effects with il17 blockers.

Which was not the case with otezla. But tnfa blockers - yeah those are bad times.

In any case, good luck with your treatment!

thank you and thanks for your n=1, wish you the best with your treatment as well

You had a skin fungal infection dumbass not some unknown mystery condition psoriasis they came up with

Wow, kid, you really have no clue about the world.