Re:Show HN: An open-source implementation of AlphaFold3
by EdHarris on Thursday September 05, 2024 @01:40PM
(#41458849)
Folding@home uses Rosetta, a physics-based approach that is outperformed by deep learning methods such as AlphaFold2/3.
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Re:Show HN: An open-source implementation of AlphaFold3
by flobosg on Friday September 06, 2024 @08:54AM
(#41465719)
Folding@home uses Rosetta only to generate initial conformations[1], but the actual simulation is based on Markov State Models. Note that there is another distributed computing project for Rosetta, Rosetta@home.
[1]: https://foldingathome.org/dig-deeper/#:~:text=employing%20Ro...