It does not invalidate science. The scientific method is the process by which we build gradually towards a clearer picture of the ground truth if there is one. Even if by “science” you just meant our current understanding of the universe as opposed to the method we gain that understanding, then this would not invalidate that, it only invalidates a small part.

Yes, we are fundamentally wrong, I would hope that all physicists recognise that we don’t have a perfect explanation for how things work yet, this would be just another step in that process, but an exciting one indeed.