I'll again say that I think it's extremely hubristic to think that human civilization has somehow figured out "most" scientific knowledge in the last couple of centuries. This human-centered attitude is not unique, though, which is kind of my point: it's not a new thing at all to think that the current level of knowledge has nowhere to go. It's just the typical human hubris that has been with us forever.
We're certainly still wrong about exotic types of matter, gravity, fundamental particles, the ways completely arbitrary things function, like genes in a cell, etc... but we know that cells exist, what they're composed of, and we're definitely not wrong about that, and that is frankly infinitely more knowledge than we've ever had before. What's left to find are mostly increasingly more nitpicky details that are nonetheless very important, but they don't change our understanding anywhere nearly as drastically.
To wrap back around to my original point, in comparison to everything else the amount of knowledge we've gained on paranormal things since tribal shaman times is about zero. It's still all hearsay and speculation and it's not for the lack of trying.
Now sure, a person during the roman times or the middle ages could be caught saying the same thing and couldn't be more wrong. And sure it's entirely possible that we'll figure something out that will revolutionize our knowledge of the universe entirely... but every time general relativity predicts yet another observation to an annoying level of perfection that chance becomes smaller and smaller.
[0] https://en.wikipedia.org/wiki/German_tank_problem