> Anti-vax people or climate change deniers also object to well-replicated results and would believe what they want to believe anyways.

Accusing your enemy of being beyond argument is just an underhanded way to avoid making an argument.

There will always be bad beliefs, we will not always know at the time which beliefs are bad, and the response to what we think are bad beliefs should be good science, not massive fraud studies on hydroxychloroquine published in one the most prominent journals in the history of medicine.