Zero calorie sweetener linked to blood clots and heart disease, study finds

Re:Zero calorie sweetener linked to blood clots and heart di... by nabla9 on Thursday August 08, 2024 @05:16PM (#41196380)

n=1 can be important if the effect size is good. What makes this n=10 (per group) is interesting and not insignificant is that there is 100% response for blood platelets "enhanced stimulus-dependent release of the platelet dense granule marker serotonin (P<0.0001 for TRAP6 [thrombin activator peptide 6] and P=0.004 for ADP) and the platelet α-granule marker CXCL4 (C-X-C motif ligand-4; P<0.0001 for TRAP6 and P=0.06 for ADP)"

There are other studies n = 1,157, n = 2,149, n = 833 and article links to some of them.

See my other comment to see better discussion and links to studies.

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Re:Zero calorie sweetener linked to blood clots and heart di... by ranger_danger on Thursday August 08, 2024 @05:33PM (#41196552)

That person could have other unknown problems though... I find it hard to believe that 1 person can ever be enough to quantify anything.

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Re:Zero calorie sweetener linked to blood clots and heart di... by nabla9 on Thursday August 08, 2024 @05:48PM (#41196685)

If you give one person rare substance X and that person dies 40 minutes later, it's enough. P < 0.000001 or at least, because people dying in 40 min time period for unrelated reason is really rare.

This study was an experiment (P<0.0001) that directly observed blood coagulation markers. Drink -> coagulation.

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