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Re:AlphaFold 3 predicts the structure and interactions of al... by lordnacho on Wednesday May 08, 2024 @07:03PM (#40303590)
The how is actually just further hypotheses. It's turtles all the way down:

There is a car. We think it drives by burning petrol somehow.

How do we test this? We take petrol away and it stops driving.

Ok, so we know it has something to do with petrol. How does it burning the petrol make it drive?

We think it is caused by the burned petrol pushing the cylinders, which are attached to the wheels through some gearing. How do we test it? Take away the gearing and see if it drives.

Anyway, this never ends. You can keep asking questions, and as long as the hypothesis is something you can test, you are doing science.

Re:AlphaFold 3 predicts the structure and interactions of al... by hammock on Wednesday May 08, 2024 @10:38PM (#40304745)
>There is a car. We think it drives by burning petrol somehow. How do we test this? We take petrol away and it stops driving.

You discovered a principle.

Better example:

There is a car. We don’t know how it drives. We turn the blinkers on and off. It still drives. Driving is useful. I drive it to the store

Re:AlphaFold 3 predicts the structure and interactions of al... by dekhn on Thursday May 09, 2024 @11:21AM (#40309147)
In the vein of "can a biologist fix a radio" and "can a neuroscientist understand a microprocessor", see https://review.ucsc.edu/spring04/bio-debate.html which is an absolutely wonderful explanation of how geneticists and biochemists would go about reverse-engineering cars.

The best part is where the geneticist ties the arms of all the suit-wearing employees and it has no functional effect on the car.