If you turn the anti-cheat off, you have to restart your computer. That is a hurdle that more than 0 users will run into.

I would argue that most people don't encounter cheaters while playing, or don't even notice them, unless blatantly obvious. In contrast, anti-cheat software like Vanguard may have a noticeable performance impact on some games, across most players.

while MOBA generally don't have cheater like fps (aimbot,wallhack,auto aim etc) but they are suffer to abuser who use script,auto clicker etc