Mixtral-8x22B-v0.1 was released a couple days ago. The "mixtral:8x22b" tag on ollama currently refers to it, so it's what you got when you did "ollama run mixtral:8x22b". It's a base model only capable of text completion, not any other tasks, which is why you got a terrible result when you gave it instructions.

Mixtral-8x22B-Instruct-v0.1 is an instruction-following model based on Mixtral-8x22B-v0.1. It was released two hours ago and it's what this post is about.

(The last updated 44 minutes ago refers to the entire "mixtral" collection.)