Let me clarify.
Mixtral-8x22B-v0.1 was released a couple days ago. The "mixtral:8x22b" tag on ollama currently refers to it, so it's what you got when you did "ollama run mixtral:8x22b". It's a base model only capable of text completion, not any other tasks, which is why you got a terrible result when you gave it instructions.
Mixtral-8x22B-Instruct-v0.1 is an instruction-following model based on Mixtral-8x22B-v0.1. It was released two hours ago and it's what this post is about.
(The last updated 44 minutes ago refers to the entire "mixtral" collection.)
And where does it say that's the instruct model?
I get:
ollama run mixtral:8x22b
Error: exception create_tensor: tensor 'blk.0.ffn_gate.0.weight' not found
You need to update ollama to 0.1.32.
https://imgur.com/a/y6XfpBl
And even the direct tag page: https://ollama.com/library/mixtral:8x22b shows 40-something minutes ago: https://imgur.com/a/WNhv70B