It is very rare that I find something stalker-blocking (pihole on my local network & VPN) causes to break that I care enough to turn blocking off for. It might have happened as little as twice, one of those occurrences predating PiHole. Information is usually in many other places or I really don't care that much, and shopping sites that break are waving a red flag by being broken so I'll go look elsewhere.
I do have a bookmarklet on my devices to turn it off for a few minutes, but that was used more when testing it then it has been since.
I mostly live alone so don't have the problem of other users, such as a spouse or kids, having trouble. Guests always have the option of using their normal mobile access instead of the local wireless if they experience insurmountable problems.
Now every time, I have an issue with any website, my first instinct is to turn off pi-hole. Most of the time, pi-hole is not the even the issue, but sometimes it is. It's annoying to browse the internet while constantly thinking "Maybe there is an issue on my side".