In my experience, the resume is so thoroughly designed to be rejected that you basically can't rely on it. I don't know how ordinary people would actually get jobs in this market by simply submitting a resume for an open requisition; there will always be someone out there whose resume has less HR red flags on it (probably because they falsified it) so you never even get an email back from hiring.

100% of my job opportunities have been from networking (or nepotism) and most of the people I know have the same experience.