The only issue I've seen is, that some apps -- Proxmox, Jitsi Meet (via jitsi-openid) -- fail to authenticate against Keycloak. Sometimes. Sometimes clearing cookies helps; sometimes not.

But the weird thing is that this failure happens only on one computer (running MacOS). I have another, with synced settings & extensions & ublock settings (running Linux) and there it always works?

For a normal, public site, I've not seen any issue.