Take one of the largest teaching hospitals in the world, Cleveland clinic is a non-profit. The Cleavland clinic 2022 annual revenue was >15 Billion and expenses were ~12 billion [0].

They have amassed an endowment fund assets such as stock, which is currently >15 Billion and growing[1]. The exact assets are confidential, but this is a snapshot from 2017, when there it was closer to 10 billion under management [2]

https://my.clevelandclinic.org/-/scassets/files/org/about/fi...

https://my.clevelandclinic.org/-/scassets/files/org/about/fi...

https://my.clevelandclinic.org/-/scassets/files/org/giving/a...