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A comment on Scientists find genetic signature of Down syndrome in ancient bones.

Re:Scientists find genetic signature of Down syndrome in anc... by inglor_cz on Thursday February 29, 2024 @04:24AM (#39547778)
It is a pity that there is no discussion if the detected amounts of extra 21 chromosome indicated a full Down syndrome or a mosaic version thereof.

In a mosaic version, only a part of your cells are trisomic, perhaps even just as little as 1/5th. In that case, the characteristic symptoms are often fewer and lighter, which would help that person survive in the Stone Age world.

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Re:Scientists find genetic signature of Down syndrome in anc... by Tabular-Iceberg on Thursday February 29, 2024 @06:10AM (#39548049)
It also seems likely that mosaic trisomy 21 is quite common but often asymptomatic. And the milder it is the lower the odds that it will be picked up even by genetic testing.
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