ForceGen: End-to-end de novo protein generation

Re:ForceGen: End-to-end de novo protein generation by nextaccountic on Saturday February 10, 2024 @10:05PM (#39332331)

Maybe off topic, but what means "de novo"? (in Portuguese it means "again" but I can't make sense of this)

This article https://en.wikipedia.org/wiki/De_novo_protein_structure_pred... also doesn't mention the etymology

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Re:ForceGen: End-to-end de novo protein generation by msla on Saturday February 10, 2024 @10:12PM (#39332365)

https://en.wiktionary.org/wiki/de_novo

> Borrowed from Latin dē novō (adverb, literally “from the new”), from dē (“from”) + novō, ablative singular of novus (“new”).

> Anew, afresh, from the beginning; without consideration of previous instances, proceedings or determinations.

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Re:ForceGen: End-to-end de novo protein generation by andreareina on Saturday February 10, 2024 @10:35PM (#39332461)

"From new". You see it in biochem when there are multiple ways to synthesize something and one of them starts from raw(er) materials. e.g. triglycerides can be made from free fatty acids or can start all the way from glucose. The pathway that starts with glucose is called "de novo lipogenesis".

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