So would probably better to get out of the galaxy disc, travel -fast- to the other end and dive back into rather that go straight through the galaxy?
Except we can't get to edge of the galaxy quickly.
I guess Hitchhikers guide to the galaxy building space highways destroying everything in the way could be more than a gag after all.
Outside galaxies you have better chances of surviving high speeds. The intergalactic medium is only 1-10 particles per cubic meter in the web of gas we call the warm–hot intergalactic medium, and possibly less outside of that.