I tried to change the keyboard layout to a more "ergonomic" layout (optimot), but after months of training, I could never gain the proficiency I have in AZERTY. I think it's not worth it to switch.
[1] https://configure.zsa.io/ergodox-ez/layouts/v56OO/latest/10
https://keychron.de/products/keychron-q11-qmk-custom-mechani...
[1]: https://keychron.de/products/keychron-v10-alice-layout-qmk-c...
[2]: https://keychron.de/products/keychron-k15-pro-alice-layout-q...
Q11 may possibly be even better for someone prone to RSI, because you can set the halves up angled even wider apart. Just make sure to get a good wrist support to go with the keyboards, no matter which you go with: they are thick, and that makes them positionally elevated from the surface they are on.
With two more things they would be pretty much perfect. An embedded USB port on both sides, so you could slot a YubiKey nano on your chosen edge. And a double-sized Esc-key. The latter is the single thing I miss from Kinesis Freestyle's form factor.
QMK itself is great, but I was never able to find a non-columnar split ISO keyboard to use it with. Eventually I reluctantly settled on the Logitech K860[2] and I'm now happily using my favourite features from QMK with kanata at the software level.
[1]: https://github.com/jtroo/kanata
[2]: If I'm behind the times and there is now a QMK-compatible keyboard that looks like this, please let me know!