if you are inexperienced, i'd start smaller and increase the weight over a few weeks as long as you feel comfortable. i think it is also important to choose a good backpack that evenly distributes your weight and doesn't pull on your shoulders.
i have never tried this myself however. i have done a lot of hiking in my youth, but i doubt my backpacks ever reached those 20%. so don't take my word for it, but double check with an expert, doctor, gym trainer, etc.
Humans have evolved to carry and run long distances and the world's militaries all ruck with 50 - 80 pounds regularly. So we're definitely "built" for this activity but of course you need to train for it.
My worry for rucking is the potential issue of back problems. I haven't seen a serious study on how weight should be properly distributed.
This can turn a 150-250 calorie an hour walk to a 300 - 600 calorie an hour walk while you're walking the same speed / socializing. It's definitely uncomfortable but doesn't interfere with socializing and thinking IMO (and of course, I'd start with 10 lbs first)
You can use sand or dumbbells but I did it often enough that I got a generic ruck plate and a high quality rucking backpack (GoRuck isn't cheap but I like their quality and the fact that they're made in America).