Seems like you are thinking from the perspective of "internal enterprise app, possibly sideloaded to use inside warehouse", or something along those lines. Those can really look like anything, but there is a high chance it will be designed and tested on a single platform anyway (since the company can purchase specific devices), so why bother with multi platform. I have seen plenty of cases like these in my work, and those apps always suck and are eventually replaced by native ones.

If you are building an app which is supposed to be used by regular end consumers, native is the only real way to go. And as prizzom mentioned, choosing native iOS toolkit is a good idea if you want to sell, because Android users are not very keen on paying for apps.