I think your build system already puts you way ahead of many distro's. And I think there can only come good for depending less on mainstream GNU utilities/libraries and systemd tools. I for one completely agree that the sourcecode of most BSD utilities is far more readable than GNU's. And it's a shame systemd is so dependant on the mainstream stack.

As for architectures, do you not run into many architecture specific problems?

I think Chimera Linux is definitely a project I want to keep an eye on.