FDA shuts down enquiries about DNA contamination in Covid vaccines

Re:FDA shuts down enquiries about DNA contamination in Covid... by rolph on Tuesday December 05, 2023 @02:35PM (#38535827)

until DNA sequences having features allowing cellular transfection [entry], and integration [inserting into host DNA] is found in vaccine, there is no basis for concern.

specific modification of a sequence of DNA is required for transfection, and integration. this is not a random occurance, and even best case outcome, is less than 10% success, and requires supportive conditions.

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Re:FDA shuts down enquiries about DNA contamination in Covid... by hammock on Tuesday December 05, 2023 @02:52PM (#38536066)

Perhaps you are right. It's an interesting area of research for sure, as the lipid nanoparticle (LNP) delivery system of these vaccines is new, and a lot of hypothesizing has been done that the residual DNA being encapsulated in the LNP makes it easier to transfect (the LNP is specifically designed to be able to enter cells) and resistant to the typical biological processes (nucleases) that would prevent integration

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Re:FDA shuts down enquiries about DNA contamination in Covid... by rolph on Tuesday December 05, 2023 @02:59PM (#38536164)

LNPs are actually better than that! they integrate with the cell membrane, and the mRNA moves through the cytoplasm.

so each cell that is ~transfected with mRNA has signature lipids in the membrane

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