I use nix to setup the python env (python version + poetry + sometimes python packages that are difficult to install with poetry) and use poetry for the rest.

The workflow is:

  > nix flake init -t github:dialohq/flake-templates#python
  > nix develop -c $SHELL
  > # I'm in the shell with poetry env, I have a shell hook in the nix devenv that does poetry install and poetry activate.