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Re:Why thinking hard makes us feel tired by tambourine_man on Thursday November 16, 2023 @10:45PM (#38299251)
It’s not. There’s no known lethal dose for LSD, for instance. And it takes only a few grams to have incredibly potent psychoactive effect
Re:Why thinking hard makes us feel tired by someplaceguy on Thursday November 16, 2023 @10:58PM (#38299373)
The estimated average lethal dose for LSD in humans is only 100 mg, based on rodent studies. Far less than caffeine and even amphetamines.

LSD does cause significant psychoactive effects with one thousandth of that amount, which suggests that for a typical isolated dose, LSD is safer than caffeine and amphetamines. Not to mention that LSD is not as addictive.

But I don't think that invalidates my underlying point regarding caffeine, even if the lethal dose is not a perfect measure.

Re:Why thinking hard makes us feel tired by tambourine_man on Friday November 17, 2023 @11:06AM (#38305440)
There’s no correlation between lethality and psychoactive strength and you’re trying to make a point based on it.
Re:Why thinking hard makes us feel tired by someplaceguy on Friday November 17, 2023 @11:36AM (#38305898)
> There’s no correlation between lethality and psychoactive strength and you’re trying to make a point based on it.

Of course there is. I think you just proved you don't understand what a correlation is...

Re:Why thinking hard makes us feel tired by tambourine_man on Friday November 17, 2023 @12:16PM (#38306582)
Here’s Wikipedia article for one of the most powerful psychoactive substances known to man:

“Overdose: There have been no documented fatal human overdoses from LSD”

https://en.m.wikipedia.org/wiki/LSD

Toxicity and psychoactivity are completely independent from one another. If you can’t understand that there’s not much else I can say to you.

Re:Why thinking hard makes us feel tired by dang on Friday November 17, 2023 @03:44PM (#38309963)
Could you please stop posting in the flamewar style and/or otherwise breaking the site guidelines? You've unfortunately been doing it repeatedly. It's not what this site is for, and destroys what it is for.

If you wouldn't mind reviewing https://news.ycombinator.com/newsguidelines.html and taking the intended spirit of the site more to heart, we'd be grateful.